Advances in Proline Ligation

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• 作者：Steven D. Townsend ; Zhongping Tan ; Suwei Dong ; Shiying Shang ; John A. Brailsford ; Samuel J. Danishefsky
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：February 29, 2012
• 年：2012
• 卷：134
• 期：8
• 页码：3912-3916
• 全文大小：325K
• 年卷期：v.134,no.8(February 29, 2012)
• ISSN：1520-5126

文摘

Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.