Solving the Convergence Problem in the Synthesis of Triantennary N-Glycan Relevant to Prostate-Specific Membrane Antigen (PSMA)

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• 作者：Maciej A. Walczak ; Samuel J. Danishefsky
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：October 3, 2012
• 年：2012
• 卷：134
• 期：39
• 页码：16430-16433
• 全文大小：336K
• 年卷期：v.134,no.39(October 3, 2012)
• ISSN：1520-5126

文摘

The first total synthesis of triantennary, fully sialylated N-glycan of complex type is described. Two strategies for installation of sialylated antennae are explored, and both approaches converge on a global glycosylation step that delivers the desired tetradecasaccharide in good yields.