Rapid and Efficient Ultrasound-Assisted Method for the Combinatorial Synthesis of Spiro[indoline-3,4鈥?pyrano[2,3-c]pyrazole] Derivatives
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- 作者：Yi Zou ; Yu Hu ; Hai Liu ; Daqing Shi
- 刊名：ACS Combinatorial Science
- 出版年：2012
- 出版时间：January 9, 2012
- 年：2012
- 卷：14
- 期：1
- 页码：38-43
- 全文大小：293K
- 年卷期：v.14,no.1(January 9, 2012)
- ISSN：2156-8944
文摘
An efficient one-pot synthesis of spiro[indoline-3,4鈥?pyrano[2,3-c]pyrazole] derivatives by four-component reaction of hydrazine, 尾-keto ester, isatin, and malononitrile or ethyl cyanoacetate catalyzed by piperidine under ultrasound irradiation is described. This synthesis was confirmed to follow the group-assistant-purification chemistry (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purifications.