Oxalyl Amide Assisted Palladium-Catalyzed Arylation of C(sp2)鈥揌 Bond at the 未 Position
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- 作者：Jian Han ; Pei Liu ; Chao Wang ; Qian Wang ; Jingyu Zhang ; Yanwei Zhao ; Daqing Shi ; Zhibin Huang ; Yingsheng Zhao
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：16
- 期：21
- 页码：5682-5685
- 全文大小：413K
- ISSN：1523-7052
文摘
A successful protocol has been developed for 未-arylation of 尾-arylethamines at the ortho position under mild conditions. The newly developed methodology first presents broad substrate scope, great functional group tolerance, and good to excellent yield in the synthesis of substituted 尾-arylethylamines. The transformation represents a practical advantage of oxalyl amide in assistance with C鈥揌 functionalization at a remote position.