Self-Assembly of Okadaic Acid as a Pathway to the Cell

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• 作者：Antonio Herná ; ndez Daranas ; Patricia G. Cruz ; Alberto Herná ; ndez Creus ; Manuel Norte ; José ; J. Ferná ; ndez
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：October 11, 2007
• 年：2007
• 卷：9
• 期：21
• 页码：4191 - 4194
• 全文大小：159K
• 年卷期：v.9,no.21(October 11, 2007)
• ISSN：1523-7052

文摘

The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of manyessential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understandthe mechanism of toxin transport across model membranes.