New Continuous Production Process for Enantiopure (2R,5R)-Hexanediol

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• 作者：Jü ; rgen Haberland ; Werner Hummel ; Thomas Daussmann ; and Andreas Liese
• 刊名：Organic Process Research & Development
• 出版年：2002
• 出版时间：July 2002
• 年：2002
• 卷：6
• 期：4
• 页码：458 - 462
• 全文大小：89K
• 年卷期：v.6,no.4(July 2002)
• ISSN：1520-586X

文摘

A new continuous production process has been developed foroptically active pure (2R,5R)-hexanediol. The process usesresting whole cells of Lactobacillus kefir DSM 20587 as abiocatalyst. The reduction of (2,5)-hexanedione to (2R,5R)-hexanediol was carried out in a 2-L continuously operatedmembrane reactor. Conversion of (2,5)-hexanedione was nearlyquantitative and the selectivity between product and intermediate was 78% for the product. Enantioselectivity and diastereoselectivity were >99% for the whole period. The productivityof L. kefir could be increased by factor 30. (2R,5R)-Hexanediolwas continuously produced over 5 days with a space-time yieldof 64 g·L^-1·d^-1.