The Mosaic of Rottlerin

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• 作者：Kenneth K. C. Hong ; Graham E. Ball ; David StC. Black ; Naresh Kumar
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：80
• 期：21
• 页码：10668-10674
• 全文大小：481K
• ISSN：1520-6904

文摘

The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C 未 (PKC未) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl₃ as a catalyst.