Synthesis-Dependent Surface Defects and Morphology of Hematite Nanoparticles and Their Effect on Cytotoxicity in Vitro

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• 作者：Dean Cardillo ; Moeava Tehei ; Md. Shahriar Hossain ; Md. Monirul Islam ; Kathrin Bogusz ; Dongqi Shi ; David Mitchell ; Michael Lerch ; Anatoly Rosenfeld ; Stéphanie Corde ; Konstantin Konstantinov
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：March 9, 2016
• 年：2016
• 卷：8
• 期：9
• 页码：5867-5876
• 全文大小：613K
• ISSN：1944-8252

文摘

In this study, we investigate the toxicity of hematite (α-Fe₂O₃) nanoparticles on the Madin-Darby Canine Kidney (MDCK) cell line. The oxide particles have been synthesized through two different methods and annealing conditions. These two methods, spray precipitation and precipitation, resulted in particles with rod-like and spherical morphology and feature different particle sizes, surface features, and magnetic properties. Through flow cytometry it was found that particle morphology heavily influences the degree to which the nanomaterials are internalized into the cells. It was also found that the ability of the nanoparticles to generate free radicals species is hindered by the formation of tetrahedrally coordinated maghemite-like (γ-Fe₂O₃) spinel defects on the surfaces of the particles. The combination of these two factors resulted in variable cytotoxic effects of the hematite nanoparticles synthesized with different conditions. This article highlights the importance on the fabrication method, materials properties, and surface characteristics on the cytotoxicity of hematite nanomaterials.