Bioactive Polychlorinated Bibenzyls from the Liverwort Riccardia polyclada

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• 作者：Cecilia Labb&#xe9 ; Francesca Faini ; Carolina Villagr&#xe1 ; n ; Josep Coll ; David S. Rycroft
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：70
• 期：12
• 页码：2019 - 2021
• 全文大小：64K
• 年卷期：v.70,no.12(December 2007)
• ISSN：1520-6025

文摘

GC-MS and ¹H NMR spectroscopic profiling of a CDCl₃ extract of the liverwort Riccardia polyclada (syn. R. umbrosa) revealed the presence of four main compounds bearing several chlorine atoms on a bibenzyl skeleton. Separation of a CH₂Cl₂ extract was achieved using preparative TLC, and structures 1–4 were proposed on the basis of spectroscopic evidence. Compounds 1–4 were active in a brine shrimp lethality bioassay (Artemia salina). In addition, 2 and 4 displayed moderate antifeedant activity in disk-choice bioassays with Spodoptera littoralis larvae and inhibited the growth of Cladosporium herbarum cultures on TLC plates.