Regioselective and Guided C鈥揌 Activation of 4-Nitropyrazoles

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• 作者：Viktor O. Iaroshenko ; Ashot Gevorgyan ; Olena Davydova ; Alexander Villinger ; Peter Langer
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：79
• 期：7
• 页码：2906-2915
• 全文大小：533K
• 年卷期：v.79,no.7(April 4, 2014)
• ISSN：1520-6904

文摘

A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H-pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevant pyrazole scaffold. The scope and limitations of the methodology were studied.