Tandem Synthesis of 3-Halo-5-Substituted Isoxazoles from 1-Copper(I) Alkynes and Dihaloformaldoximes

详细信息    查看全文

• 作者：Wenwen Chen ; Bo Wang ; Nan Liu ; Dayun Huang ; Xinyan Wang ; Yuefei Hu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：December 5, 2014
• 年：2014
• 卷：16
• 期：23
• 页码：6140-6143
• 全文大小：374K
• ISSN：1523-7052

文摘

A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.