Pipestelides A鈥揅: Cyclodepsipeptides from the Pacific Marine Sponge Pipestela candelabra
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- 作者：Jonathan Sorres ; Marie-Th茅r猫se Martin ; Sylvain Petek ; H茅l猫ne Levaique ; Thierry Cresteil ; Suzanne Ramos ; Odile Thoison ; C茅cile Debitus ; Ali Al-Mourabit
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：April 27, 2012
- 年：2012
- 卷：75
- 期：4
- 页码：759-763
- 全文大小：274K
- 年卷期：v.75,no.4(April 27, 2012)
- ISSN：1520-6025
文摘
Pipestelides A鈥揅 (2鈥?b>4) are three new NRPS鈥揚KS hybrid macrolides containing uncommon moieties, isolated from the Pacific marine sponge Pipestela candelabra. Their structures were elucidated on the basis of spectroscopic data. These cyclodepsipeptides appear to be biosynthetically related to jaspamide (aka jasplakinolide) (1) by chemical modification of the building blocks of the polyketide or peptide chains. Pipestelides A鈥揅 (2鈥?b>4) contain a bromotyrosine [3-amino-3-(bromo-4-hydroxyphenyl)propanoic acid] unit, a polypropionate with a Z double bond, and a 2-hydroxyquinolinone, respectively. Revised chemical shift assignments are provided for the co-isolated known jasplakinolide Ca (5). In addition, compounds 2 and 3 exhibited cytotoxic activities in the micromolar range.