Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization

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• 作者：Chongyi Chen ; Decheng Wu ; Wenxin Fu ; Zhibo Li
• 刊名：Biomacromolecules
• 出版年：2013
• 出版时间：August 12, 2013
• 年：2013
• 卷：14
• 期：8
• 页码：2494-2498
• 全文大小：429K
• 年卷期：v.14,no.8(August 12, 2013)
• ISSN：1526-4602

文摘

Three alkyl-polypeptide (AP) amphiphiles were prepared using ring-opening polymerization of 伪-amino acid N-carboxyanhydride. The polypeptide segment was composed of diethylene-glycol-monomethyl-ether-functionalized poly-l-glutamate (poly-l-EG₂Glu). These AP amphiphiles can spontaneously self-assemble into transparent hydrogels in water. These hydrogels showed shear thinning properties, and their strength can be modulated by hydrophobic alkyl tails. CryoTEM and AFM characterizations suggested that these hydrogels were formed by nanoribbons arising from intermolecular interactions between nonionic poly-l-EG₂Glu segments.