Chromium-Catalyzed Regioselective Hydropyridination of Styrenes

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• 作者：Yuexuan Li ; Gongda Deng ; Xiaoming Zeng
• 刊名：Organometallics
• 出版年：2016
• 出版时间：March 14, 2016
• 年：2016
• 卷：35
• 期：5
• 页码：747-750
• 全文大小：375K
• ISSN：1520-6041

文摘

The first chromium-catalyzed regioselective addition of para-C–H bonds of pyridines across styrenes is disclosed. The hydrofunctionalization reaction was promoted by a low-cost chromium(III) chloride combining with a cyclohexyl Grignard reagent and 2,2′-bipyridine, which allows for the highly selective formation of branched products via the cleavage of inert C–H bonds of pyridines.