Divergent Photocyclization/1,4-Sigmatropic Rearrangements for the Synthesis of Sesquiterpenoid Derivatives
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- 作者：Evgueni Gorobets ; Norman E. Wong ; Robert S. PatonDarren J. Derksen
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 3, 2017
- 年：2017
- 卷：19
- 期：3
- 页码：484-487
- 全文大小：420K
- ISSN：1523-7052
文摘
Combined experimental and computational efforts have demonstrated the utility of divergent photocyclization/1,4-sigmatropic rearrangement reactions for developing a general strategy toward the synthesis of cubebane-, spiroaxane-, and guaiane-type sesquiterpenes and related analogues. The configuration of the bridgehead substituent, the choice of solvent, and the wavelength of irradiation all impact diastereoselectivity in this tandem reaction process.