Redox-Active Biomolecular Architectures and Self-Assembled Monolayers Based on a Cyclodecapeptide Regioselectively Addressable Functional Template

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• 作者：Charles H. Devillers ; Didier Boturyn ; Christophe Bucher ; Pascal Dumy ; Pierre Labbé ; Jean-Claude Moutet ; Guy Royal ; Eric Saint-Aman
• 刊名：Langmuir
• 出版年：2006
• 出版时间：September 12, 2006
• 年：2006
• 卷：22
• 期：19
• 页码：8134 - 8143
• 全文大小：283K
• 年卷期：v.22,no.19(September 12, 2006)
• ISSN：1520-5827

文摘

A nanometer scale redox active biomolecular architecture has been successfully synthesized through an efficientchemoselective oxime based coupling between ferrocenyl groups and a regioselectively addressable cyclodecapeptide.This molecular tool exhibits electronic, structural, and chemical properties driven by the biomimetic recognitionactivity of the polypeptide skeleton associated to the well-defined electrochemical activity of metallocenyl probes.Biomolecular materials obtained by confinement of the redox cyclopeptide in self-assembled monolayers on goldsurfaces shows efficient through-bond electron transfer from the ferrocenes to the electrode surface via the peptidicbackbone, as well as markedly improved sensing properties toward anionic species in organic electrolyte, as comparedto those observed in homogeneous solution.