Efficient One-Pot Synthesis of Highly Substituted Pyridin-2(1H)-ones via the Vilsmeier-Haack Reaction of 1-Acetyl,1-Carbamoyl Cyclopropanes

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• 作者：Wei Pan ; Dewen Dong ; Kewei Wang ; Jie Zhang ; Rigenhada Wu ; Dexuan Xiang ; Qun Liu
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：June 7, 2007
• 年：2007
• 卷：9
• 期：12
• 页码：2421 - 2423
• 全文大小：76K
• 年卷期：v.9,no.12(June 7, 2007)
• ISSN：1523-7052

文摘

A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier-Haack reaction of readilyavailable 1-acetyl,1-carbamoyl cyclopropanes, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophiliccyclization reactions is proposed.