A Facile and Efficient Synthesis of Polyfunctionalized Pyridin-2(1H)-ones from -Oxo Amides under Vilsmeier Con

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• 作者：Dexuan Xiang ; Kewei Wang ; Yongjiu Liang ; Guangyuan Zhou ; Dewen Dong
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：January 17, 2008
• 年：2008
• 卷：10
• 期：2
• 页码：345 - 348
• 全文大小：103K
• 年卷期：v.10,no.2(January 17, 2008)
• ISSN：1523-7052

文摘

A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of -oxo amides under Vilsmeier conditions isdescribed, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.