Vilsmeier-Haack Reactions of 2-Arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the Synthesis of Highly Substituted Pyridin-2(1H)-ones

详细信息    查看全文

• 作者：Dexuan Xiang ; Yang Yang ; Rui Zhang ; Yongjiu Liang ; Wei Pan ; Jie Huang ; Dewen Dong
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：October 26, 2007
• 年：2007
• 卷：72
• 期：22
• 页码：8593 - 8596
• 全文大小：66K
• 年卷期：v.72,no.22(October 26, 2007)
• ISSN：1520-6904

文摘

A facile and efficient one-pot synthesis of highly substitutedpyridin-2(1H)-ones was developed via Vilsmeier-Haackreactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involvingsequential ring-opening, haloformylation, and intramolecularnucleophilic cyclization reactions is proposed.