Comparative Evaluation of Antioxidant Potential of Alaternin (2-Hydroxyemodin) and Emodin
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- 作者：Jae Sue Choi ; Hae Young Chung ; Hyun Ah Jung ; Hye Jin Park ; and Takako Yokozawa
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2000
- 出版时间：December 2000
- 年：2000
- 卷：48
- 期：12
- 页码：6347 - 6351
- 全文大小：53K
- 年卷期：v.48,no.12(December 2000)
- ISSN：1520-5118
文摘
The antioxidant activities of alaternin (2-hydroxyemodin) and emodin were compared for theirrespective potentials to inhibit lipid peroxidation in the linoleic acid system by the thiocyanatemethod, to inhibit total reactive oxygen species generation in kidney homogenates using 2',7'-dichlorodihydrofluorescein diacetate, to inhibit peroxynitrite formation by the 3-morpholinosydnonimine system, which generates superoxide radical and nitrogen monooxide, and to scavengeauthentic peroxynitrites. Both alaternin and emodin were found to inhibit the peroxidation of linoleicacid by the thiocyanate method in a dose-dependent manner. Whereas the former shows inhibitoryactivities in reactive oxygen- and nitogen-mediated reactions, the latter does not. These resultsindicate that alaternin is a potentially effective and versatile antioxidant and can be used to protectbiological systems and functions against various oxidative stresses.Keywords: Alaternin; emodin; anthraquinone; peroxynitrite; lipid peroxidation; antioxidant; Cassiatora