Antifungal Agents from Pseudallescheria boydii SNB-CN73 Isolated from a Nasutitermes sp. Termite

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• 作者：Charlotte Nirma ; V茅ronique Eparvier ; Didier Stien
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：May 24, 2013
• 年：2013
• 卷：76
• 期：5
• 页码：988-991
• 全文大小：187K
• 年卷期：v.76,no.5(May 24, 2013)
• ISSN：1520-6025

文摘

Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum.