Introducing Undergraduates to Research Using a Suzuki鈥揗iyaura Cross-Coupling Organic Chemistry Miniproject
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- 作者：Deyvid G. M. Oliveira ; Clarissa H. Rosa ; Bruna P. Vargas ; Diego S. Rosa ; M谩rcia V. Silveira ; Neusa F. de Moura ; Gilber R. Rosa
- 刊名：Journal of Chemical Education
- 出版年：2015
- 出版时间：July 14, 2015
- 年：2015
- 卷：92
- 期：7
- 页码：1217-1220
- 全文大小：235K
- ISSN：1938-1328
文摘
A five-week miniproject is described for an upper-division experimental organic chemistry course. The activities include synthesis of a phenylboronic acid via a Grignard reaction and its use in a Suzuki鈥揗iyaura cross-coupling reaction. Technical skills and concepts normally presented in practical organic chemistry courses are covered, including the use of an inert atmosphere (Schlenk tube technique), separation of mixtures (filtration), melting range determination, infrared (IR) spectrum, stoichiometric calculations and gas chromatography techniques.