Natural Diels鈥揂lderases: Elusive and Irresistable

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• 作者：Kimberly Klas ; Sachiko Tsukamoto ; David H. Sherman ; Robert M. Williams
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：December 4, 2015
• 年：2015
• 卷：80
• 期：23
• 页码：11672-11685
• 全文大小：919K
• ISSN：1520-6904

文摘

Eight examples of biosynthetic pathways wherein a natural enzyme has been identified and claimed to function as a catalyst for the [4 + 2] cycloaddition reaction, namely, Diels鈥揂lderases, are briefly reviewed. These are discussed in the context of the mechanistic challenges associated with the technical difficulty of proving that the net formal [4 + 2] cycloaddition under study indeed proceeds through a synchronous mechanism and that the putative biosynthetic enzyme deploys the pericyclic transition state required for a Diels鈥揂lder cycloaddition reaction.