Syntheses of the C1鈥揅14 and C15鈥揅25 Fragments of Amphidinolide C

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• 作者：Dimao Wu ; Craig J. Forsyth
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：15
• 期：6
• 页码：1178-1181
• 全文大小：245K
• 年卷期：v.15,no.6(March 15, 2013)
• ISSN：1523-7052

文摘

Divergent syntheses of the C1鈥揅14 and C15鈥揅25 fragments of amphidinolide C have been achieved. The synthesis of the C15鈥揅25 fragment featured cobalt-catalyzed modified Mukaiyama aerobic alkenol cyclization and sulfur-directed regiocontrolled Wacker oxidation of an internal alkene. The C1鈥揅14 fragment was established by alkenyllithium addition to an aldehyde followed by a challenging olefination of a highly inert C9 ketone.