Metabolic Fingerprint of Dimethyl Sulfone (DMSO2) in Microbial鈥揗ammalian Co-metabolism

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• 作者：Xuan He ; Carolyn M. Slupsky
• 刊名：Journal of Proteome Research
• 出版年：2014
• 出版时间：December 5, 2014
• 年：2014
• 卷：13
• 期：12
• 页码：5281-5292
• 全文大小：423K
• ISSN：1535-3907

文摘

There is growing awareness that intestinal microbiota alters the energy harvesting capacity of the host and regulates metabolism. It has been postulated that intestinal microbiota are able to degrade unabsorbed dietary components and transform xenobiotic compounds. The resulting microbial metabolites derived from the gastrointestinal tract can potentially enter the circulation system, which, in turn, affects host metabolism. Yet, the metabolic capacity of intestinal microbiota and its interaction with mammalian metabolism remains largely unexplored. Here, we review a metabolic pathway that integrates the microbial catabolism of methionine with mammalian metabolism of methanethiol (MT), dimethyl sulfide (DMS), and dimethyl sulfoxide (DMSO), which together provide evidence that supports the microbial origin of dimethyl sulfone (DMSO₂) in the human metabolome. Understanding the pathway of DMSO₂ co-metabolism expends our knowledge of microbial-derived metabolites and motivates future metabolomics-based studies on ascertaining the metabolic consequences of intestinal microbiota on human health, including detoxification processes and sulfur xenobiotic metabolism.

Keywords:

DMSO₂; dimethyl sulfone; methylsulfonylmethane; dimethyl sulfoxide; dimethyl sulfide; methanethiol; hydrogen sulfide; intestinal microbiota; metabolism; metabolome