Direct N-Acetyl Enamine Formation: Lithium Bromide Mediated Addition of Methyllithium to Nitriles

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• 作者：Cé ; cile G. Savarin ; Geneviè ; ve N. Boice ; Jerry A. Murry ; Edward Corley ; Lisa DiMichele ; Dave Hughes
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：August 31, 2006
• 年：2006
• 卷：8
• 期：18
• 页码：3903 - 3906
• 全文大小：57K
• 年卷期：v.8,no.18(August 31, 2006)
• ISSN：1523-7052

文摘

An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. Theresulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very low catalyst loading.