Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl Chlorides

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• 作者：Xiaodan Zhao ; Elena Dimitrijevi ; Vy M. Dong*
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：March 18, 2009
• 年：2009
• 卷：131
• 期：10
• 页码：3466-3467
• 全文大小：162K
• 年卷期：v.131,no.10(March 18, 2009)
• ISSN：1520-5126

文摘

Selective C−H bond functionalization enables efficient access to valuable products from relatively simple precursors and thus remains a longstanding challenge in organic synthesis. This communication highlights the discovery of arylsulfonyl chlorides as readily available, inexpensive, and versatile reagents for C−H bond functionalization. A novel Pd-catalyzed synthesis of arylsulfones that features a rare C−H bond activation/functionalization to form a C−S bond is presented. By simple alterations of the reaction parameters, Pd-catalyzed C−Cl and C−C bond formation can also be achieved using arylsulfonyl chlorides as the oxidant.