β-Carboline Alkaloids from Stellaria dichotoma var. lanceolata and Their Anti-inflammatory Activity

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• 作者：Yuh-Fung Chen ; Ping-Chung Kuo ; Hsiu-Hui Chan ; I-Je Kuo ; Fu-Wen Lin ; Chung-Ren Su ; Mei-Lin Yang ; Ding-Tzai Li ; Tian-Shung Wu
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：December 27, 2010
• 年：2010
• 卷：73
• 期：12
• 页码：1993-1998
• 全文大小：201K
• 年卷期：v.73,no.12(December 27, 2010)
• ISSN：1520-6025

文摘

The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III−XIV (1−12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC₅₀ values in the range of 11.3 to 19.3 μM.