Remote-Controlled Drug Release from Graphene Oxide-Capped Mesoporous Silica to Cancer Cells by Photoinduced pH-Jump Activation

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• 作者：Dinggeng He ; Xiaoxiao He ; Kemin Wang ; Zhen Zou ; Xue Yang ; Xuecai Li
• 刊名：Langmuir
• 出版年：2014
• 出版时间：June 24, 2014
• 年：2014
• 卷：30
• 期：24
• 页码：7182-7189
• 全文大小：365K
• ISSN：1520-5827

文摘

Remote light control of drug release enhances our ability to address the complexity of biological systems because of its remarkable spatial/temporal resolution. Here, a new class of remote-controlled release system by incorporating photoacid generator (PAG) into graphene oxide-capped mesoporous silica was designed for delivering drug payloads to cancer cells via photoinduced pH-jump activation. PAG was immobilized on pore wall of the boronic acid-grafted mesoporous silica via strong physical adsorption, and then the nanoparticle was capped with graphene oxide sheet by an acid-labile boroester bond, leading to the formation of nanogated ensemble (MSP-BA-GO). Illuminating with a UV light, PAG generated a pH jump, which induced cleavage of the boroester linkers and thus resulted in the uncapping of pore gates. Moreover, folic acid-modified, doxorubicin (DOX)-loaded MSP-BA-GO (DOX@MSP-BA-GOF) showed selective cell internalization via receptor-mediated endocytosis and subsequent released DOX by the remote illumination. We envisioned that this remote-controlled drug delivery system could find potential applications for cancer therapy.