Structure of the Human Telomere in K+ Solution: An Intramolecular (3 + 1) G-Quadruplex Scaffold

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• 作者：Kim Ngoc Luu ; Anh Tuâ ; n Phan ; Vitaly Kuryavyi ; Laurent Lacroix ; Dinshaw J. Patel
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：August 2, 2006
• 年：2006
• 卷：128
• 期：30
• 页码：9963 - 9970
• 全文大小：735K
• 年卷期：v.128,no.30(August 2, 2006)
• ISSN：1520-5126

文摘

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologicallyrelevant K⁺ solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously inNa⁺ solution and in a K⁺-containing crystal, involves the following: one anti·syn·syn·syn and two syn·anti·anti·anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in onedirection and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplexscaffold should provide a unique platform for structure-based anticancer drug design targeted to humantelomeric DNA.