A Protocol To Generate Phthaloyl Peroxide in Flow for the Hydroxylation of Arenes

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• 作者：Anders M. Eliasen ; Randal P. Thedford ; Karin R. Claussen ; Changxia Yuan ; Dionicio Siegel
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：16
• 期：14
• 页码：3628-3631
• 全文大小：264K
• ISSN：1523-7052

文摘

A flow protocol for the generation of phthaloyl peroxide has been developed. This process directly yields phthaloyl peroxide in high purity (>95%) and can be used to bypass the need to isolate and recrystallize phthaloyl peroxide, improving upon earlier batch procedures. The flow protocol for the formation of phthaloyl peroxide can be combined with arene hydroxylation reactions and provides a method for the consumption of peroxide as it is generated to minimize the accumulation of large quantities of peroxide.