Hydroxyl-Directed Cyclizations of 1,6-Enynes
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- 作者：Andrew M. Camelio ; Thomas Barton ; Fenghai Guo ; Travis Shaw ; Dionicio Siegel
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：March 18, 2011
- 年：2011
- 卷：13
- 期：6
- 页码：1517-1519
- 全文大小：686K
- 年卷期：v.13,no.6(March 18, 2011)
- ISSN：1523-7052
文摘
The palladium-catalyzed, hydroxyl-directed cyclization reactions of 1,6-enynes provide a highly diastereoselective process for the syntheses of stereochemically defined cyclopentanes. Consistently high levels of cis-selectivity are possible using homopropargyl alcohols in contrast to the corresponding propargyl alcohols. Hydroborylative enyne cyclizations coupled with this directing group effect provide a useful method for the syntheses of multifaceted compounds bearing all carbon quaternary centers.