Integration of Enzymatic Catalysts in a Continuous Reactive Distillation Column: Reaction Kinetics and Process Simulation

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• 作者：Rene Heils ; Alexander Niesbach ; Matthias Wierschem ; Dierk Claus ; Sebastian Soboll ; Philip Lutze ; Irina Smirnova
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2014
• 出版时间：December 17, 2014
• 年：2014
• 卷：53
• 期：50
• 页码：19612-19619
• 全文大小：404K
• ISSN：1520-5045

文摘

This work presents a feasibility study for an enzymatic reaction in a continuously operated reactive distillation column. As a model reaction, the transesterification of ethyl butyrate with n-butanol in the presence of lipase CALB was considered. For use in the distillation column, lipase CALB was immobilized by entrapment in a hydrophobic silica xerogel and introduced as granulate into the catalytic packing Katapak-SP-11. The reaction kinetics was experimentally determined for different concentration and temperature ranges and described by means of the Michaelis鈥揗enten double-substrate kinetic model in combination with the Arrhenius model. With these kinetic data, process simulations were carried out with an Aspen Custom Modeler nonequilibrium-stage model validated for a DN50 pilot-scale column. The concentration of n-butanol in the reactive section was maintained low to decrease the inhibiting effects on the enzyme. For an optimized setup and operating conditions, conversion rates of more than 90% were achieved for n-butanol and 26% for ethyl butyrate. These results clearly demonstrate that lipase CALB can be applied in a continuously operated reactive distillation column.