DNA Origami Nanopores
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- 作者：Nicholas A. W. Bell ; Christian. R. Engst ; Marc Ablay ; Giorgio Divitini ; Caterina Ducati ; Tim Liedl ; Ulrich F. Keyser
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：January 11, 2012
- 年：2012
- 卷：12
- 期：1
- 页码：512-517
- 全文大小：320K
- 年卷期：v.12,no.1(January 11, 2012)
- ISSN：1530-6992
文摘
We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of 位-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.