Ruthenium(II)-Catalyzed Alkenylation of Ferrocenyl Ketones via C鈥揌 Bond Activation

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• 作者：Keisham S. Singh ; Pierre H. Dixneuf
• 刊名：Organometallics
• 出版年：2012
• 出版时间：November 12, 2012
• 年：2012
• 卷：31
• 期：21
• 页码：7320-7323
• 全文大小：265K
• 年卷期：v.31,no.21(November 12, 2012)
• ISSN：1520-6041

文摘

The alkenylation with alkyl acrylates of ferrocenyl alkyl ketones is performed with the [RuCl₂(p-cymene)]₂ /AgSbF₆ catalytic system and leads, via ferrocene C鈥揌 bond activation, to moderate yields of the 1,2-disubstituted ferrocene derivatives in the presence of Cu(OAc)₂路H₂O under aerobic conditions at 80鈥?10 掳C. The alkenylation of ferrocenyl phenyl ketone, in contrast, takes place at room temperature to afford quantitative yields of the phenyl monoalkenylated product, demonstrating the strong influence of the ferrocenyl group on arene C鈥揌 bond functionalization. Small amounts of 2-alkenylferrocenyl 2鈥?phenyl ketones can also be obtained.