Isothermal vapor鈥搇iquid equilibrium (VLE) data were measured for the binary systems of octafluoropropane + octafluorocyclobutane and hexafluoropropylene oxide + octafluorocyclobutane system at the temperature range from 263.15 K to 303.15 K. The experiments were carried out with a circulating-type equilibrium apparatus including online gas chromatography analysis. The VLE data were correlated well by the Peng鈥揜obinson equation of state using the Wong鈥揝andler mixing rules involving the NRTL model. All the binary parameters of these systems and the average absolute deviations (AADs) in terms of saturated pressure and vapor phase composition between the experimental and calculated values are represented.