Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines
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- 作者：Mlina Girardin* ; Pamela G. Alsabeh ; Sophie Lauzon ; Sarah J. Dolman ; Stphane G. Ouellet ; Greg Hughes
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：March 5, 2009
- 年：2009
- 卷：11
- 期：5
- 页码：1159-1162
- 全文大小：140K
- 年卷期：v.11,no.5(March 5, 2009)
- ISSN：1523-7052
文摘
A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.