Antibacterial Action of 4,4鈥?Bipyrazolyl-Based Silver(I) Coordination Polymers Embedded in PE Disks

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• 作者：Aurel T膬b膬caru ; Claudio Pettinari ; Fabio Marchetti ; Corrado di Nicola ; Konstantin V. Domasevitch ; Simona Galli ; Norberto Masciocchi ; Stefania Scuri ; Iolanda Grappasonni ; Mario Cocchioni
• 刊名：Inorganic Chemistry
• 出版年：2012
• 出版时间：September 17, 2012
• 年：2012
• 卷：51
• 期：18
• 页码：9775-9788
• 全文大小：771K
• 年卷期：v.51,no.18(September 17, 2012)
• ISSN：1520-510X

文摘

Coupling the rigid spacer 4,4鈥?bipyrazole (H₂BPZ), in its anionic or neutral form, to different silver(I) salts allowed isolation of the novel coordination polymers [Ag₂(BPZ)] (1) and [Ag(H₂BPZ)(X)] (X = NO₃, 2; ClO₄, 3; BF₄, 4; PF₆, 5; CH₃SO₃, 6; CF₃SO₃, 7), which were fully characterized by infrared and emission spectroscopies, thermal analysis, and X-ray powder diffraction. The crystal structure of 1 consists of 2-D layers containing 1-D chains of Ag(I) ions bridged by exo-tetradentate bipyrazolato moieties. The crystal structures of the [Ag(H₂BPZ)(X)] species 2鈥?b>7 feature 1-D chains of [Ag(H₂BPZ)] stoichiometry, along which the metal centers are bridged by exo-bidentate bipyrazolyl spacers. Contacts among adjacent chains are mediated by the counterions through nonbonding interactions involving the Ag(I) ions and the pyrazolyl N鈥揌 groups. Thermogravimetric analyses disclosed the good thermal stability of these materials, decomposing in the range 200鈥?00 掳C. Under UV irradiation at room temperature, all the species showed a yellow-green emission centered in the range 520鈥?22 nm. When embedded into polyethylene disks, 1, 2, and 4鈥?b>7 demonstrated their activity as topical antibacterial agents against suspensions of E. coli, P. aeruginosa, and S. aureus: complete reduction of the three bacterial strains was achieved in 24 h, reduction of S. aureus reaching ca. 90% in only 2 h. Biocidal action was expressed also by contact susceptibility tests.