In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography

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• 作者：Santiago Rojas ; Juan Domingo Gispert ; Sergio Abad ; Mireia Buaki-Sogo ; Victor M. Victor ; Hermenegildo Garcia ; Jose Ra煤l Herance
• 刊名：Molecular Pharmaceutics
• 出版年：2012
• 出版时间：December 3, 2012
• 年：2012
• 卷：9
• 期：12
• 页码：3543-3550
• 全文大小：361K
• 年卷期：v.9,no.12(December 3, 2012)
• ISSN：1543-8392

文摘

A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with ¹⁸F to study their in vivo biodistribution in rats by positron emission tomography (PET). The ¹⁸F isotope was anchored by reaction of N-succinimidyl 4-[¹⁸F]fluorobenzoate (¹⁸F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.

Keywords:

ceria nanoparticles; PET; pharmacokinetics; in vivo evaluation; rodent