Clusters of Superparamagnetic Iron Oxide Nanoparticles Encapsulated in a Hydrogel: A Particle Architecture Generating a Synergistic Enhancement of the T2 Relaxation

详细信息    查看全文

• 作者：Chantal Paquet ; Hendrick W. de Haan ; Donald M. Leek ; Hung-Yu Lin ; Bo Xiang ; Ganghong Tian ; Arnold Kell ; Benoit Simard
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：April 26, 2011
• 年：2011
• 卷：5
• 期：4
• 页码：3104-3112
• 全文大小：917K
• 年卷期：0
• ISSN：1936-086X

文摘

Clusters of iron oxide nanoparticles encapsulated in a pH-responsive hydrogel are synthesized and studied for their ability to alter the T₂-relaxivity of protons. Encapsulation of the clusters with the hydrophilic coating is shown to enhance the transverse relaxation rate by up to 85% compared to clusters with no coating. With the use of pH-sensitive hydrogel, difficulties inherent in comparing particle samples are eliminated and a clear increase in relaxivity as the coating swells is demonstrated. Agreement with Monte Carlo simulations indicates that the lower diffusivity of water inside the coating and near the particle surface leads to the enhancement. This demonstration of a surface-active particle structure opens new possibilities in using similar structures for nanoparticle-based diagnostics using magnetic resonance imaging.