Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp. shj2
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- 作者：Bing-Chao Yan ; Wei-Guang Wang ; Dong-Bao Hu ; Xiang Sun ; Ling-Mei Kong ; Xiao-Nian Li ; Xue Du ; Shi-Hong Luo ; Yan Liu ; Yan Li ; Han-Dong Sun ; Jian-Xin Pu
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：March 4, 2016
- 年：2016
- 卷：18
- 期：5
- 页码：1108-1111
- 全文大小：299K
- ISSN：1523-7052
文摘
Phomopchalasins A (1) and B (2), two novel cytochalasans with unprecedented carbon skeletons, and phomopchalasin C (3), containing a rare hydroperoxyl motif, were obtained from the endophytic fungus Phomopsis sp. shj2, which was first isolated from the Isodon eriocalyx var. laxiflora. Their structures were elucidated by extensive spectroscopic analyses, electronic circular dichroism (ECD) calculation, and X-ray crystallographic analysis. Notably, 1 possessed an unprecedented 5/6/5/8-fused tetracyclic ring system, and 2 featured a novel 5/6/6/7/5-fused pentacyclic skeleton. The cytotoxic, anti-inflammatory, and antimigratory activities of 1–3 were evaluated in vitro.