Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines

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• 作者：Jun Jiang ; Hua-Dong Xu ; Jian-Bei Xi ; Bai-Yan Ren ; Feng-Ping Lv ; Xin Guo ; Li-Qin Jiang ; Zhi-Yong Zhang ; Wen-Hao Hu
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 8, 2011
• 年：2011
• 卷：133
• 期：22
• 页码：8428-8431
• 全文大小：773K
• 年卷期：v.133,no.22(June 8, 2011)
• ISSN：1520-5126

文摘

The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh₂(OAc)₄ and chiral Br酶nsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-伪-substituted 伪,尾-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity.