Regioselective Hydroacylation of 1,3-Dienes by Cobalt Catalysis

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• 作者：Qing-An Chen ; Daniel K. Kim ; Vy M. Dong
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：March 12, 2014
• 年：2014
• 卷：136
• 期：10
• 页码：3772-3775
• 全文大小：316K
• 年卷期：v.136,no.10(March 12, 2014)
• ISSN：1520-5126

文摘

We describe a cobalt-catalyzed hydroacylation of 1,3-dienes with non-chelating aldehydes. Aromatic aldehydes provide 1,4-addition products as the major isomer, while aliphatic aldehydes favor 1,2-hydroacylation products. The kinetic profile supports an oxidative cyclization mechanism involving a cobaltacycle intermediate that undergoes transformation with high regio- and stereoselectivity.