Rhodium-Catalyzed Hydrofunctionalization: Enantioselective Coupling of Indolines and 1,3-Dienes
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- 作者：Xiao-Hui Yang ; Vy M. Dong
- 刊名：Journal of the American Chemical Society
- 出版年：2017
- 出版时间：February 8, 2017
- 年：2017
- 卷：139
- 期：5
- 页码：1774-1777
- 全文大小：470K
- ISSN：1520-5126
文摘
We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C–C, C–O, C–S, and C–N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio- and enantioselectivity. Tuning both the pKa and steric properties of an acid-additive is critical for enantiocontrol.