Au-Doped Magnetic Silica Nanotube for Binding of Cysteine-Containing Proteins
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- 作者：Doo Ri Bae ; Soo Jin Lee ; Sang Woo Han ; Jung Mi Lim ; Dongmin Kang ; Jong Hwa Jung
- 刊名：Chemistry of Materials
- 出版年：2008
- 出版时间：June 24, 2008
- 年：2008
- 卷：20
- 期：12
- 页码：3809 - 3813
- 全文大小：904K
- 年卷期：v.20,no.12(June 24, 2008)
- ISSN：1520-5002
文摘
The Au-doped magnetic silica nanotube (Au-MSNT) was fabricated by sol−gel transcription and its binding ability for proteins was carried out by TEM, FT-IR, and confocal microscope. The nickel nanoparticles with 3.5 
1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) with 220 nm diameter. In addition, the Au-MSNT clearly revealed the Au nanoparticles with 9.3 2.0 nm diameter. The Au-MSNT carried out the binding ability for protein as a guest molecule. The Au-MSNT acted as a receptor for the selective molecular recognition of biomolecules, particularly proteins containing cysteine. On the other hand, ubiquitin, which has no cysteine groups, was not immobilized onto the Au-MSNT. These results indicate that the Au-MSNT is efficiently recognized by the cysteine-containing protein.
1.0 nm are homogeneously deposited on the inner side of a silica nanotube (SNT) with 220 nm diameter. In addition, the Au-MSNT clearly revealed the Au nanoparticles with 9.3 2.0 nm diameter. The Au-MSNT carried out the binding ability for protein as a guest molecule. The Au-MSNT acted as a receptor for the selective molecular recognition of biomolecules, particularly proteins containing cysteine. On the other hand, ubiquitin, which has no cysteine groups, was not immobilized onto the Au-MSNT. These results indicate that the Au-MSNT is efficiently recognized by the cysteine-containing protein.