Chelation-Assisted Palladium-Catalyzed Cascade Bromination/Cyanation Reaction of 2-Arylpyridine and 1-Arylpyrazole C−H Bonds

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• 作者：Xiaofei Jia ; Dongpeng Yang ; Wenhui Wang ; Fang Luo ; Jiang Cheng
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：December 18, 2009
• 年：2009
• 卷：74
• 期：24
• 页码：9470-9474
• 全文大小：783K
• 年卷期：v.74,no.24(December 18, 2009)
• ISSN：1520-6904

文摘

A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C−H bonds has been developed. Notably, the reaction employs K₃[Fe(CN)₆] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.