Exploring the Toxicity of a Bismuth鈥揂sparagine Coordination Polymer on the Early Development of Zebrafish Embryos

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• 作者：Ningning He ; Xiang Li ; Daofu Feng ; Ming Wu ; Rui Chen ; Tiehong Chen ; Dongyan Chen ; Xizeng Feng
• 刊名：Chemical Research in Toxicology
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：26
• 期：1
• 页码：89-95
• 全文大小：432K
• 年卷期：v.26,no.1(January 18, 2013)
• ISSN：1520-5010

文摘

Nanoparticles are widely used in nanomedicine, raising concerns about their toxicity. In this study, the toxicity of bismuth鈥揳sparagine coordination polymer spheres (BACP-2) was assessed in zebrafish embryos. Injection of 1鈥? cell stage embryos with BACP-2 resulted in smaller head size (particularly smaller eye size), shorter body length, and pericardial edemas. The severity and occurrence of the resulting phenotype were concentration-dependent. The expression of genes such as krox20, orthodenticle homeobox 2 (otx2), and cardiac myosin light chain-2 (cmlc2) indicates that the effects of BACP-2 on the head and heart were related to changes in gene expression patterns. A delay in epiboly was observed, and the expression levels of the no tail (ntl) gene indicated that the delay in epiboly resulted both from the effect of BACP-2 on cell migration during epiboly and from slow growth. These findings indicate that BACP-2 exhibits concentration-dependent developmental toxicity, providing insight into the nanotoxicity of bismuth derivatives, which must be rigorously evaluated with respect to toxicity before their application in nanomedicine.