Ti-Catalyzed Homolytic Opening of Ozonides: A Sustainable C鈥揅 Bond-Forming Reaction
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- 作者：Antonio Rosales ; Juan Mu帽oz-Basc贸n ; Crist贸bal L贸pez-S谩nchez ; M铆riam 脕lvarez-Corral ; Manuel Mu帽oz-Dorado ; Ignacio Rodr铆guez-Garc铆a ; J. Enrique Oltra
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：April 20, 2012
- 年：2012
- 卷：77
- 期：8
- 页码：4171-4176
- 全文大小：282K
- 年卷期：v.77,no.8(April 20, 2012)
- ISSN：1520-6904
文摘
The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C鈥揅 bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A.