Practical Syntheses of Oxindole Derivatives: Chemical Development towards 2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)acetamide and (S)-2-(5-Chloro-2-oxo-2,3-dihydroindol-1-yl)propionamide

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• 作者：Fabienne Broeders ; Laurent Defrre ; Marie-France Deltent ; Frank Driessens ; Frdric Gilson ; Luc Grooters ; Xavier Ikonomakos ; Frdric Limauge ; Emmanuel Sergeef ; Natacha Verstraeten
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：May 15, 2009
• 年：2009
• 卷：13
• 期：3
• 页码：442-449
• 全文大小：222K
• 年卷期：v.13,no.3(May 15, 2009)
• ISSN：1520-586X

文摘

We describe development of scalable syntheses of novel oxindole-type SV2A ligands with improved potency towards seizure suppression.