One-Pot Modular Synthesis of Functionalized RAFT Agents Derived from a Single Thiolactone Precursor

详细信息    查看全文

• 作者：Steven Martens ; Frank Driessen ; Sofie Wallyn ; Oğuz Türünç ; Filip E. Du Prez ; Pieter Espeel
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：August 16, 2016
• 年：2016
• 卷：5
• 期：8
• 页码：942-945
• 全文大小：243K
• 年卷期：0
• ISSN：2161-1653

文摘

In this paper, the straightforward preparation of a range of functionalized trithiocarbonates as RAFT chain transfer agents (CTAs) is presented. The crucial step in the one-pot, three-step reaction sequence is the aminolysis of a thiolactone precursor as it introduces the desired functional handle (double bond, hydroxyl, furan, protected amine, ...) and generates the corresponding thiol in situ, facilitating further elaboration of the CTA. Furthermore, the newly synthesized trithiocarbonates were positively evaluated as mediators in the RAFT polymerization of styrene, isobornyl acrylate, and N-isopropylacrylamide, while the presence of the end groups in the heterotelechic polymers was confirmed by NMR and UV–vis analysis.